- Title
- An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals
- Creator
- Micallef, M. A.; Munro, I. A.; Garg, M. L.
- Relation
- European Journal of Clinical Nutrition Vol. 63, Issue 9, p. 1154-1156
- Publisher Link
- http://dx.doi.org/10.1038/ejcn.2009.20
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2009
- Description
- High sensitivity C-reactive protein (hs-CRP) is a marker of low-grade sustained inflammation. Omega-3 (n-3) fatty acids have anti-inflammatory properties and are associated with reduced cardiovascular disease (CVD) risk. The aim of this study was to investigate whether plasma n-3 fatty acid concentration is related to hs-CRP concentration. A total of 124 free-living adults, were divided into tertiles of plasma hs-CRP (<1.0, 1.0–3.0 and >3.0 mg/l). Body composition and anthropometric measurements were recorded. Hs-CRP was analysed using immunoassays and fatty acids were measured by gas chromatography. Plasma hs-CRP concentration was negatively correlated with total n-3 fatty acids (P=0.05), eicosapentaenoic acid (EPA; P=0.002) and docosapentaenoic acid (DPA; P=0.01). The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk.
- Subject
- C-reactive protein; omega-3 fatty acids; cardiovascular disease; inflammation
- Identifier
- uon:8243
- Identifier
- http://hdl.handle.net/1959.13/917204
- Identifier
- ISSN:0954-3007
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